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A slightly more subtle modification of this hypothesis also takes into account the total time needed for blood to cross a particular tissue so that part of the bound hormone can be released during tissue perfusion to replace the free hormone taken up by cells during this tissue perfusion. This implies that the real available hormone is higher than the static free hormone concentration due to dissociation of free hormone during tissue perfusion, halotestin mma. A large number of biochemical, cellular, and physiologic data strongly support this free hormone hypothesis. The serum transport of 25OHD and 1,25(OH) 2 D also likely behaves as the other steroid or thyroid hormones.
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